Response to stress is not necessarily pathological

The sphingosine rheostat is involved in the cnidarian heat stress response but not necessarily in bleaching.

Sphingolipids play important roles in mitigating cellular heat and oxidative stress by altering membrane fluidity, receptor clustering and gene expression. Accumulation of signaling sphingolipids that comprise the sphingosine rheostat, pro-apoptotic sphingosine (Sph) and pro-survival sphingosine-1-phosphate (S1P) is key to determining cell fate. Reef-building corals and other symbiotic cnidaria...

Success is not necessarily automatic

There are a number of factors (planning, process optimization, organizational structure, people development and the need to see the total picture) that must be in place for automation to be as effective as possible. This paper discusses these factors and their relationship with automation. It evaluates less obvious areas associated with automation, as well as the more established ones, and disc...

Why causing death is not necessarily morally equivalent to allowing to die--a response to Ferguson.

Response to Winter: 'Hardcore smoking does not necessarily indicate hardening'.

This is a post-print (post-refereed, final accepted) version of the manuscript that has been published in Addiction. The citation details and the link to the final publisher version are below. Docherty, G., McNeill, A., Gartner, C. E. and Szatkowski, L. (2014), Response to Winter: ‘Hardcore smoking does not necessarily indicate hardening’. Addiction, 109: 682. doi: 10.1111/add.12462 Published o...

Randomized trial of brief motivational treatments for pathological gamblers: More is not necessarily better.

The efficacy of brief treatments for media-recruited pathological gamblers was tested in a randomized clinical trial design (N = 314). Two self-directed motivational interventions were compared with a 6-week waiting list control and a workbook only control. Brief motivational treatment involved a telephone motivational interview and a mailed self-help workbook. Brief motivational booster treatm...